EFFICACY AND SAFETY OF LIPID-LOWERING THERAPIES IN COMBINATION WITH OR WITHOUT STATIN TO REDUCE THE CARDIOVASCULAR RISK: A SYSTEMATIC REVIEW OF RANDOMISED CONTROLLED TRIALS

Efficacy and safety of lipid-lowering therapies in combination with or without statin to reduce the cardiovascular risk: A systematic review of randomised controlled trials

Background and aims: Cardiovascular diseases (CVD) pose a significant global health burden.Lowering low-density lipoprotein-cholesterol is the primary therapeutic aim for preventing primary and secondary CVD events.While statins are the standard treatments, their limitations, such as side effects and intolerance in certain patient groups, necessita

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A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells

Prostate cancer (PC) is one of the most widespread malignancies among males worldwide.The androgen receptor (AR) plays Gift Card a major role in prostate cancer development and progression and is the main target of PC therapy.Nonetheless, its action is not yet fully elucidated.We report here that the AR associates with Filamin A (FlnA) promoting mi

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